This formulation should be administered by a health care professional as deep IM deltoid or gluteal injection do not administer IV.For patients who have never taken oral risperidone, it is recommended to establish tolerability with the oral formulation prior to initiating treatment with long acting injection.Titration dose: May increase to 37.5 mg or 50 mg if needed dose titration should occur no more frequently than every 4 weeks as expected drug release starts 3 weeks after injection.Patients should be periodically reassessed to determine the continued need for treatment.Patients who respond to acute treatment doses should be maintained on the effective dose beyond the acute episode.Doses above 12 mg per day were not demonstrated to be more efficacious and were associated with more extrapyramidal symptoms and other adverse effects.May be administered orally once a day or in divided doses twice a day.Maintenance dose: 2 to 8 mg orally per day.Titration dose: May increase in increments of 1 to 2 mg per day at interval of 24 hours or more, as tolerated.
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